Corvalol

Corvalol

Corvalol is a combined drug. It has sedative and antispasmodic effect, facilitates the onset of natural sleep. Corvalol is an effective remedy for functional disorders of the cardiovascular system, neurosis-like states, accompanied by increased irritability, violations of sleep, tachycardia, excitation states.


Active substance:

each tablet contains:
ethyl alpha-bromo-isovaleric acid - 8.2 mg;
phenobarbital - 7.5 mg;
peppermint oil - 0,58 mg;

Pharmachologic effect:

sedative
Phenobarbital has sedative and mild hypnotic effects. It helps reduce CNS excitation and facilitates offensive of natural sleep.
Ethyl alpha-bromo-isovaleric acid has sedative and antispasmodic action.
Peppermint oil has a reflex vasodilator and spasmolytic activity.

Pharmacodynamics:


Corvalol is a combined drug. It has a sedative and antispasmodic effect, facilitates the onset of natural sleep.
Ethyl bromisovalerianate has a sedative (similar to the effect of valerian) and antispasmodic effect due to irritation, mainly of the receptors of the oral cavity and nasopharynx, a decrease in reflex excitability in the central parts of the nervous system and increased inhibition in the neurons of the cortex and subcortical structures of the brain, as well as a decrease in the activity of the central vasomotor centers and a direct local antispasmodic effect on smooth muscles.
Phenobarbital has a sedative (in small doses), hypnotic, muscle relaxant and antispasmodic effects, helps to reduce the excitation of the central nervous system (CNS) and facilitates the onset of sleep, enhances the sedative effect of other components.
Peppermint leaf oil has a reflex vasodilatory effect, antispasmodic, mild choleretic, antiseptic action. The mechanism of action is associated with the ability to irritate the "cold" receptors of the oral mucosa and reflexively expand mainly the vessels of the heart and brain. Peppermint leaf oil eliminates the phenomena of flatulence due to irritation of the receptors of the mucous membrane of the gastrointestinal tract, enhancing intestinal peristalsis.

Indications:


Corvalol prescribed as a sedative and vasodilator in functional disorders of the cardiovascular system, neuro dystonia,for neurosis-like states accompanied by increased irritability, disturbance of sleep, tachycardia, a state of excitement with autonomic manifestations. Also as an antispasmodic for bowel spasms.

Contraindications:


Hypersensitivity to the drug; The expressed disturbances of function of kidneys and / or liver disease, pregnancy, lactation

Pregnancy and breast-feeding:


The use of Corvalol during pregnancy and during breastfeeding is contraindicated, since the drug contains phenobarbital, which crosses the placenta and has a teratogenic effect, has a negative effect on the formation and further functioning of the central nervous system of the fetus and newborn; Phenobarbital penetrates into breast milk, the development of physical dependence in the newborn is possible. If necessary, the use of the drug during breastfeeding should resolve the issue of stopping breastfeeding with breast milk.


Side effects:


Corvalol is usually well tolerated. In some cases, during the day may experience drowsiness and dizzy.
With prolonged use of high doses may develop chronic poisoning bromine, manifestations of which are: depressed mood, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired motor coordination, drug dependency.
With long-term use of the drug, the formation of drug dependence is possible , also accumulation of bromine in the body and development of the bromism phenomena.

Interaction:


Corvalol increases the effects of sedatives, antipsychotics, tranquilizers, ethanol.
The action of Corvalol is enhanced by the use of valproic acid preparations.

Dosing and Administration:


The dosage and duration of treatment established by the doctor for each patient individually. For adults usually 1 -2 tablets of Corvalol 2-3 times a day before meals.
If tachycardia - the single dose can be increased to 3 tablets.

Overdose:


Symptoms:
Depression of the central nervous system, nystagmus, ataxia, lowering blood pressure, agitation, dizziness, weakness, chronic bromine intoxication (depression, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination of movements).
Treatment:
Discontinuation of the drug, gastric lavage and symptomatic therapy, with CNS depression - caffeine, nikethamide.

Special instructions:
The drug contains phenobarbital, so patients taking Corvalol should refrain from driving and engaging in other potentially hazardous activities that require increased concentration and psychomotor speed.


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Corvalol
in Cyrillic : Корвалол
SUBSTANCE
Phenobarbital + Peppermint leaf oil + Etylbromisovalerianate
DOSAGE FORM
20 tablets

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