Sumatriptan

Active substance:

Sumatriptan

Pharmachologic effect:

Sumatriptan is a selective serotonin receptor agonist that works by narrowing blood vessels around the brain. It also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms.

Indications:

• Acute treatment of migraine attacks with or without aura in adults.

Contraindications:

• Hypersensitivity to sumatriptan or any of its components
• History of myocardial infarction
• Coronary artery disease or coronary vasospasm
• Peripheral vascular disease
• Stroke or transient ischemic attack
• Uncontrolled hypertension
• Severe hepatic impairment
• Concomitant use with ergotamine or its derivatives
• Concomitant use with another 5-HT1 receptor agonist

Side effects:

In order of decreasing probability: Dizziness, Drowsiness, Flushing, Tingling or numbness, Nausea, Dry mouth, Feeling of heaviness or tightness, Muscle pain, Chest discomfort

Dosing and Administration:

The recommended dose for adults is a single 50 mg tablet taken orally with water. Some patients may require a 100 mg dose. If the migraine persists or returns, a second dose may be taken at least 2 hours after the first dose. Do not exceed 200 mg in 24 hours.

Storage:

Store at a temperature not exceeding 30°C (86°F).

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