Clenbuterol

Clenbuterol

Clenbuterol is a bronchodilator, also used in sports as a fat burner and metabolism accelerator.
It is one of most popular drugs in athletes who want to get rid of body fat without losing muscle mass.
Clenbuterol is used medicinally to widen the airways and reduce shortness of breath. Works as a beta-2 agonist, similar to ephedrine.
  • Release of fatty acids.
  • Reduces adipose tissue by increasing the production of adrenaline.
  • The person's temperature rises.
  • The metabolism is accelerated.
  • Appetite decreases.
  • Suppresses the production of the catabolic hormone cortisol. That is, it helps prevent muscle breakdown.
In addition, it has a weak anabolic property. But this is less pronounced than fat burning and anti-catabolic properties.
All in all, Clenbuterol helps you burn fat while keeping your muscles from breaking down. The perfect combination for drying!

Clenbuterol for weight loss: instructions for use

Clenbuterol should be taken for two weeks, then 2 weeks break, and 2 weeks repeat again.
It is better to drink it before lunch or dinner, dividing the dosage into two parts:
  • The first day: take 20 mcg tablet
  • The second day: take 40 mcg (2 tablets)
  • The third day: take 60 mcg (3 tablets)
  • The fourth day: drink 80 mcg (4 tablets)
  • The fifth day: leave 100 mcg (5 tablets)
  • From 6 to 12 days: take 100 mcg;
  • Day 13: take 80 mcg;
  • Day 14: take 40 mcg

The daily dose of Clenbuterol for weight loss:

  • 140 mcg - for men;
  • 100 mcg - for women

Combined uses with other drugs

  1. An excellent combination would be taking Clenbuterol at a dosage of 120-160mcg with Metformin (2500mg). Thus, these drugs manage to enhance the actions of each other. Clenbuterol in this case helps to eliminate the negative property of metformin, in particular, the feeling of fatigue.
  2. Anabolic steroids such as oxandrolone and testosterone also have the ability to enhance the effect of clenbuterol.
  3. It is recommended to combine the Clenbuterol with triiodothyronine only for experienced athletes.


Pharmachologic effect:

adrenomimetic, bronchodilator.

Pharmacodynamics:


Clenbuterol is a drug with a rapid bronchodilator effect. Its action is due to the specific stimulation of β2-adrenergic receptors of smooth muscles. When bound to them, the enzyme adenylate cyclase is activated, which leads to an increase in the intracellular concentration of cyclic adenosine monophosphate and activation of protein kinase A, and deprives myosin of the ability to combine with actin, resulting in relaxation of the bronchi. Clenbuterol stimulates the cells of the bronchial mucosa and enhances expectoration. At prescribed therapeutic doses, clenbuterol does not affect heart rate or blood pressure.

Pharmacokinetics:


Clenbuterol is relatively rapidly absorbed from the gastrointestinal tract. Communication with plasma proteins is 89-98%. The biological T1/2 is 3.5 hours. Clenbuterol is excreted mainly through the kidneys in the form of sulfo-conjugated derivatives.

Indications:


Bronchial asthma, chronic obstructive bronchitis, pulmonary emphysema and other lung diseases with broncho-obstructive syndrome.

Contraindications:


thyrotoxicosis;
hypertrophic obstructive cardiomyopathy;
angle-closure glaucoma;
pheochromocytoma;
tachyarrhythmia;
myocardial infarction (acute period);
pregnancy (I and III trimester);
lactation period;
children's age up to 6 years;
hypersensitivity to the active substance or to any of the excipients.

Use with caution:


Use with caution immediately after a myocardial infarction, with liver and kidney failure, heart rhythm disturbances, myocarditis, mitral valve defects, hypokalemia, unstable or uncompensated diabetes.

Pregnancy and breast-feeding:


Clenbuterol is contraindicated in the I trimester of pregnancy and just before birth.

Side effects:


Cardio-vascular system and blood: tachycardia, arrythmia, reduction or (more often) increase in blood pressure. Nervous system and sensory organs: the tremor of fingers, anxiety, headache. Digestive tract: dry mouth, nausea. Allergic reactions: skin rash, urticaria. Other: hypokalemia.

Interaction:


Beta-blockers inhibit the action of Clenbuterol, and when they are taken simultaneously, there is a risk of developing bronchospasm.
The use of the drug simultaneously with hypoglycemic agents reduces their effect.
Clenbuterol enhances the action and side effects of beta-agonists, theophylline and anticholinergics.
With the simultaneous use of clenbuterol and halogenated hydrocarbons for anesthesia (with manipulations and interventions), there is an increased risk of arrhythmia.
Clenbuterol can be used simultaneously with diuretics and cardiac glycosides, but with periodic monitoring of serum electrolytes.
With simultaneous use with MAO inhibitors (tricyclic antidepressants), cardiac arrhythmias are possible.

Dosing and Administration:


Adults and children over 12 years - 10-20 mcg 2-3 times a day, maintenance dose - 10 mcg 2 times a day.
Young children - in small doses, depending on the age, 2 times a day.
The duration of the course of treatment with Clenbuterol is 2-3 days, until the acute symptoms of the disease are relieved.
The duration of maintenance therapy should not exceed 7 days. The decision on treatment for a period exceeding seven days is made by the attending physician.

Overdose:


Symptoms: tremor of the extremities, restlessness, tachycardia. Treatment: dose reduction, symptomatic therapy

Special instructions:
The drug contains the so-called parabens as excipients: methyl parahydroxybenzoate and propyl parahydroxybenzoate, which can cause urticaria and contact dermatitis (delayed-type allergic reactions). Rarely, immediate allergic reactions (bronchospasm) may occur.
The drug contains glycerol as an auxiliary substance, which at high doses can cause headache, stomach irritation and diarrhea.
The drug contains 0.63 vol.% of ethyl alcohol. Each dose contains 0.005 g of alcohol per 1 ml. It is dangerous for people with liver disease, alcoholism, epilepsy, brain damage or disease, as well as for pregnant women and children. May enhance the effect of other medicines.
The drug is not suitable for patients with congenital fructose intolerance due to the presence of sorbitol in it.
In the first days of treatment, clenbuterol can cause slight tremors and restlessness, which requires increased caution when driving a car and working with machinery.


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Clenbuterol
in Cyrillic : Кленбутерол
SUBSTANCE
Сlenbuterol
DOSAGE FORM
50 tablets
MANUFACTURER

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