Methotrexate-Ebewe
Methotrexate-Ebeve is a medication primarily used to treat rheumatoid arthritis and certain other autoimmune conditions. This oral tablet works by inhibiting the growth of specific cells, which helps reduce inflammation and slows joint damage. It is also commonly prescribed for treating severe psoriasis and certain types of cancer by interfering with cell division. Methotrexate is part of a class of drugs known as antimetabolites. The medication is usually taken weekly, with the dosage customized based on the individual's condition and response to treatment. It is crucial for patients to adhere to the prescribed regimen to achieve optimal benefits.Active substance:
MethotrexatePharmachologic effect:
Methotrexate is an antimetabolite and antifolate drug. It inhibits the enzyme dihydrofolate reductase, interfering with DNA synthesis, repair, and cellular replication. It is used primarily in the treatment of cancer and autoimmune diseases.Indications:
- Rheumatoid arthritis
- Psoriasis
- Certain types of cancer, including breast cancer, lung cancer, lymphoma, and leukemia
Contraindications:
- Hypersensitivity to methotrexate or any of its components
- Severe hepatic impairment
- Severe renal impairment
- Pre-existing blood disorders
- Pregnancy and breastfeeding
- Alcoholism or chronic liver disease
Side effects:
In order of decreasing probability: Common: Nausea, vomiting, diarrhea, stomatitis, Less common: Dizziness, headache, fatigue, Rare: Hepatotoxicity, nephrotoxicity, pulmonary toxicity, Very rare: Severe skin reactions, bone marrow suppression
Dosing and Administration:
For rheumatoid arthritis and psoriasis, the typical starting dose is 7.5 mg once weekly, which may be adjusted based on patient response and tolerance. For cancer treatment, dosing varies widely depending on the type and stage of cancer, and it should be determined by an oncologist.
Storage:
Store at a temperature not exceeding 25°C (77°F).
Methotrexate-Ebewe
in Cyrillic : Метотрексат-Эбеве
SUBSTANCE
Methotrexate
DOSAGE FORM
tablets
