Methotrexate
Methotrexate is an antimetabolite medication primarily used to treat autoimmune disorders such as rheumatoid arthritis and psoriasis. It is also effective in managing certain types of cancer, including leukemia and lymphomas. Methotrexate works by inhibiting the metabolism of folic acid, which is necessary for cell reproduction, thus slowing down the growth of rapidly dividing cells. Available in tablet form, Methotrexate offers a convenient oral administration method. It is often used as part of a comprehensive treatment plan and may be combined with other medications for enhanced effectiveness. Methotrexate is widely recognized for its role in reducing inflammation and controlling disease progression.Active substance:
MethotrexatePharmachologic effect:
Methotrexate is an antimetabolite and antifolate drug that inhibits the metabolism of folic acid. It is used to treat certain types of cancer and autoimmune diseases by interfering with the growth of rapidly dividing cells.Indications:
- Rheumatoid arthritis
- Psoriasis
- Acute lymphoblastic leukemia
- Non-Hodgkin's lymphoma
- Breast cancer
- Lung cancer
Contraindications:
- Pregnancy
- Breastfeeding
- Severe liver impairment
- Alcoholism
- Blood disorders
- Immunodeficiency syndromes
Side effects:
In order of decreasing probability: Nausea, Vomiting, Diarrhea, Stomatitis, Fatigue, Dizziness, Headache, Hair loss, Decreased blood cell counts, Liver function abnormalities
Dosing and Administration:
The dosage of Methotrexate varies based on the condition being treated. For rheumatoid arthritis, the typical starting dose is 7.5 mg once weekly, which may be adjusted based on response and tolerability. For psoriasis, the dose may range from 10 to 25 mg per week. In cancer treatment, dosing is highly individualized and should be determined by a healthcare professional.
Storage:
Store at a temperature not exceeding 25°C (77°F).
Methotrexate
in Cyrillic : Метотрексат
SUBSTANCE
Methotrexate
DOSAGE FORM
tablets
