Azathioprine
Azathioprine is a medication used primarily to suppress the immune system. It is commonly administered in capsule form to manage autoimmune diseases such as rheumatoid arthritis and inflammatory bowel disease. Azathioprine works by inhibiting the proliferation of certain cells in the immune system, thereby reducing inflammation and tissue damage. This medication is also used in organ transplantation to prevent the body from rejecting transplanted organs. Azathioprine's effectiveness in reducing immune response makes it a critical component in the treatment of chronic inflammatory conditions. Regular monitoring through blood tests is often recommended to ensure proper dosage and to prevent potential complications. It is usually taken orally, with dosing tailored to the specific needs of the patient.Active substance:
AzathioprinePharmachologic effect:
Azathioprine is an immunosuppressive medication that works by inhibiting the proliferation of cells, particularly leukocytes, which are involved in the immune response. It is used to prevent the body from rejecting transplanted organs and to treat autoimmune diseases by reducing the activity of the immune system.Indications:
- Prevention of organ rejection in kidney transplantation
- Rheumatoid arthritis
- Systemic lupus erythematosus
- Autoimmune hepatitis
- Inflammatory bowel diseases such as Crohn's disease and ulcerative colitis
Contraindications:
- Hypersensitivity to azathioprine or any of its components
- Pregnancy and breastfeeding
- Severe liver or kidney impairment
- Active infections
Side effects:
In order of decreasing probability: Nausea, Vomiting, Diarrhea, Loss of appetite, Increased risk of infections, Leukopenia, Thrombocytopenia, Hepatotoxicity, Pancreatitis, Alopecia
Dosing and Administration:
The recommended initial dose for adults is 1 to 3 mg/kg per day, taken orally in divided doses. The maintenance dose is typically 1 to 2 mg/kg per day. Dosage should be adjusted based on clinical response and blood counts. It is important to follow the prescribing physician's instructions and adjust the dose as needed.
Storage:
Store at a temperature not exceeding 25°C (77°F).
Azathioprine
in Cyrillic : Азатиоприн
SUBSTANCE
Azathioprine
DOSAGE FORM
capsules
